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影片疏失：
- Continuity: At the end, Sebastian pulls Linda through a water puddle. Her shirt becomes dark because of the water absorbed. The next shot, it's light again.
- Continuity: Caine is seen in the monitor to be lying on the bed, but the mattress is not indented.
- Continuity: Caine's skin becomes visible when it chars, for no reason consistent with the other invisibility. Further, it drops off in an impossible way (since there's no indication the invisibility otherwise changes metabolism/healing). Caine acts far too healthy for someone so severely burned. Finally, the extreme damage to skin and muscles that this implies is not seen when he becomes visible. (Even if the material flaking off is clothing, most of the arguments still apply; burned clothing would adhere to burned skin, and would provide little to no protection from the fire.)
- Continuity: Just before the big explosion, the hallways were filled with water. When the camera tracks the explosion through the hallways, there is no water present, not even vapor that should have been present if the heat generated from the explosion was enough to vaporise it that fast.
- Continuity: Latex smeared on end of breathing tube disappears in subsequent scene.
- Continuity: Linda pulls a frozen tear from her face. If a tear freezes that fast, the water on her eyeballs should be frozen too.
- Continuity: Matt is bitten by the gorilla, but in the next scene where it's strapped to the table, his hand is fine. Shortly after the gorilla is made visible, his hand is suddenly bandaged.
- Continuity: Sometimes the mattress retains heat (as seen through the monitor) after Caine gets up, other times it does not.
- Continuity: The blood comes off Sebastian impossibly quickly; he has no time to take a shower, and blood is somewhat sticky (though not as sticky as fake blood).
- Continuity: The blue paint sprayed on the gorilla's arm to help them find a vein disappears as she becomes visible.
- Continuity: The blue spray on Sebastian's arm when the scientists tried bring him back to visibility.
- Continuity: The images on the heat monitor screens do not match the images of the actors, especially at the beginning when a visible Caine pets an invisible dog.
- Continuity: When Caine shot Linda first, it was in her heart, then they showed her again it was in the middle of her ribcage, and again they showed her and it wasn't there.
- Continuity: When Dr. McKay pushes open the freezer door, she is standing behind the row of wires still connected to the door. A moment later, without moving, she is on the other side of them.
- Continuity: When Linda and Matt are trying to escape from the freezer, the amount of blood changes on the door lock.
- Continuity: When Matt hits Sebastian in the middle of the head and looks at (the visible) Sebastian he is looking at the wrong spot - he is looking beside Sebastian.
- Continuity: When pouring the face mold on Caine's invisible head to make the mask it appears as though his head is shaved completely bald, yet in later scenes (swimming pool) it is clear that he has hair. No bald cap or similar covering is shown protecting the hair, but without it, the hair would become embedded in the latex.
- Continuity: When Sebastian is electrocuted he is standing in the same water as Matthew and Linda, the electric current would have traveled through (thus killing) them too.
- Continuity: When the eye holes are first cut in the latex mask, they are rough-edged and sloppy. Later they are perfectly rounded.
- Continuity: When the mask is first made, the mouth opening is a large, sloppy, rounded hole. Later the mask fits tightly to Caine's lips.
- Continuity: When they put the reversal liquid into the ape a rubber band was used to help find the blood vessel. When they did the same thing for Sebastian no rubber band was used but they were quickly successful at finding the vessel.
- Crew or equipment visible: When Sebastian is stalking his neighbor, there is a brief moment where you can see the reflection of camera crew in the window looking into Sebastian's apartment.
- Factual errors: An electromagnet is used to pull a metal lever on the other side of a metal door. The metal door would shield the lever, making this impossible.
- Factual errors: Duct tape would not stick to bloody skin at 40 below zero, and probably not at higher temperatures.
- Factual errors: Due to braking mechanisms and the fact that the elevator floor was at the same level as the lab floor, the fire would not have pushed the elevator upward. Instead it would have come up through the access panel that they opened, and possibly blown the top of the elevator off.
- Factual errors: McKay repeatedly touches metal objects at below-freezing temperature with bare hands. This should cause severe injury from cold burns (or at least more discomfort than we see).
- Factual errors: Nitroglycerin cannot be simply mixed up in a matter of a minute or so. It requires careful and precise work (ideally under a fume hood), and very careful watching (the mixture has to be within a slim temperature range or it'll either not form nitro or explode prematurely). Also, nitroglycerin requires nitric acid in addition to the sulfuric we see him use.
- Factual errors: The braking system on lifts (elevators) is designed to stop a free-falling car safely and quickly (using gravity and a wedge system). It would not take a long time to stop the car or break up as shown in the film.
- Factual errors: The gorilla is referred to as "she" yet when "she" becomes visible, it has a silver back. Silverbacks are the dominant male of a gorilla group.
- Factual errors: The pressurized tanks of flammable liquid that Linda uses to make a flamethrower are sitting unsecured in the lab. OSHA regulations require pressurized cylinders to be secured to prevent them from tipping over. The danger is that the top will get knocked off, and the tank will shoot around like a rocket. Any lab would have their tanks secured for this reason.
- Factual errors: The wire to a de-fib paddle is used as a constant power source for a powerful electromagnet. This isn't possible as the power source for a de-fib paddle is a capacitor which would only be able to emit a brief burst of charge.
- Factual errors: Walk-in coolers and freezers are required by building codes and OSHA regulations to have release mechanisms from the inside to prevent one's getting locked in. They usually provide warm coats as well, especially when the work requires one to spend extended periods of time inside the unit.
- Factual errors: When Caine injects himself with the fluid to make him invisible, you see bubbles going through the tube into his arm. These bubbles, once in his veins, would cause severe pain (though are probably not enough to kill him). Hence doctors in real life flick the bubbles to the top of syringe and squirt them out. At the least, a medical professional injecting air would be highly unprofessional.
- Factual errors: When Linda and Matt are trapped in the freezer, we get a shot of a thermometer dropping about 15 degrees in less than 2 seconds. This would require abnormally powerful cooling equipment, which is not shown (and which this lab would have no reason to own).
- Factual errors: When the other scientists do CPR on Caine, they are not in a position to do effective compressions. However, *real* CPR breaks ribs, so this "acting" facsimile ought really to be allowed.
- Incorrectly regarded as goofs: Since the viewing goggles used infrared radiation for seeing invisible objects, they could not see through a metal locker. However, the woman in the locker was leaning against, and hence warming, the door, and its her warmth that was shown.
- Plot holes: After being electrocuted and hit over the head with a crowbar, Sebastian is still very much alive and in good shape, considering. No mention is ever made that the invisibility serum also provides the subject with invulnerability and superhuman strength. A normal man would be killed if he were hit over the head with a crowbar. Also, lying on top of uninsulated steam pipes would have burned Caine, as would the escaping steam.
- Plot holes: Numerous problems inherent to the "invisible man" premise are completely ignored. Some examples: Since light passes through the retina Sebastian would be blind. The soles of his feet would be visible from the dirt picked up by walking barefoot. The food he eats becomes immediately invisible.
- Plot holes: The elevator to enter the lab requires a visible-light thumb scan, but Caine enters the lab (and apparently not by following someone) after he has become invisible. A fingerprint is not sufficient for the type of scanner shown. (A deleted scene shows that this was originally acknowledged and that Caine sneaked onto the elevator when someone else used the scanner.)
- Plot holes: When locked in the freezer, why didn't Linda simply yank out a few of the obvious hanging wires behind the refrigeration unit?